نتایج جستجو برای: undercarboxylated osteocalcin
تعداد نتایج: 4017 فیلتر نتایج به سال:
To study the correlations between serum osteocalcin and glucose metabolism in patients with type 2 diabetes, 66 cases were collected to determine total osteocalcin, undercarboxylated osteocalcin, fasting blood glucose, fasting insulin, and HbA1c. Osteocalcin concentrations were compared between groups of different levels of HbA1c, and parameters of glucose metabolism were compared between group...
Vitamin K is essential for bone health, but the effects of low-dose vitamin K intake in Japanese subjects remain unclear. We investigated the effective minimum daily menaquinone-7 dose for improving osteocalcin γ-carboxylation. Study 1 was a double-blind, randomized controlled dose-finding trial; 60 postmenopausal women aged 50-69 y were allocated to one of four dosage group and consumed 0, 50,...
We developed a RIA involving a polyclonal antibody against bovine osteocalcin, which has a carboxy-terminal epitope. Although the antibody recognizes both native and descarboxy osteocalcin, the two forms of osteocalcin were differentiated by adsorption to barium sulfate, taking advantage of the calcium-binding properties of the vitamin K-dependent gla domain. To test the clinical application of...
Global energy balance in mammals is controlled by the actions of circulating hormones that coordinate fuel production and utilization in metabolically active tissues. Bone-derived osteocalcin, in its undercarboxylated, hormonal form, regulates fat deposition and is a potent insulin secretagogue. Here, we show that insulin receptor (IR) signaling in osteoblasts controls osteoblast development an...
BACKGROUND Menaquinone-4 is a type of vitamin K that has a physiological function in maintaining bone quality via γ-carboxylation of osteocalcin. However, little is known about the beneficial effect of intake of dosages below1500 μg/day. FINDINGS Fifteen healthy males aged 25.0 years (median) participated in a non-placebo-controlled dose-examination study. They received menaquinone-4 daily fo...
results the findings indicated that ucoc%/oc% was positively and significantly associated with percentage change in max force production during elbow extension (β = 0.28, p = 0.034), however, all other associations were non-significant. background muscles and bones are interconnected. recent studies suggest that undercarboxylated osteocalcin from bone may affect muscle mass and strength. there ...
ABSTRACT Background and Objective: The present study aims at investigating the possible effect of 8-week aerobic exercise on undercarboxylated osteocalcin and beta cell function in postmenopausal women. Methods: The study included 20 postmenopausal women with mean weight, height and b...
Osteocalcin is the most abundant noncollagenous protein of bone matrix. Once transcribed, this protein undergoes posttranslational modifications within osteoblastic cells before its secretion, including the carboxylation of three glutamic residues in glutamic acid, which is essential for hydroxyapatite binding and deposition in the extracellular matrix of bone. Recent provocative data from expe...
Background: Undercarboxylated Osteocalcin (ucOC) may contribute to the regulation of glucose homeostasis. Undercarboxylated osteocalcin is special protein secreted by bone as an endocrine regulation of energy metabolism and glucose. It plays an important role in insulin secretion and sensitivity. The aim of this study was to survey the effect of eight weeks resistance training on serum levels o...
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